{"id":2233,"date":"2015-04-29T07:28:14","date_gmt":"2015-04-29T07:28:14","guid":{"rendered":"http:\/\/www.neb-online.fr\/?page_id=2233"},"modified":"2022-11-14T11:00:58","modified_gmt":"2022-11-14T10:00:58","slug":"glycobiology","status":"publish","type":"page","link":"https:\/\/www.neb-online.fr\/en\/glycobiology\/","title":{"rendered":"Glycobiology"},"content":{"rendered":"

[vc_row][vc_column width=”1\/1″][vc_column_text]The relevance of glycobiology goes beyond the importance for basic studies of cell biology. Currently, glycoprotein and carbohydrate-based drugs and therapeutics represent a greater than $20 billion market (1-4).<\/p>\n

A very important set of therapeutic glycoproteins are recombinant monoclonal antibodies<\/a> (rMAbs). They can effectively inhibit TNF-\u03b1 and thus control the symptoms of rheumatoid arthritis, multiple sclerosis and other autoimmune diseases. Oncological applications include the use of rMAbs to target malignant cells to prevent tumor proliferation.<\/p>\n

Recent progress in chemical synthesis and bioengineering resulted in the development of many carbohydrate-based vaccines, some of which also have applications in cancer treatment. Finally, it must be mentioned that one of the oldest drug agents to date is Heparin<\/a>, a proteoglycan that is still widely used to successfully treat a broad range of conditions.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/1″][vc_separator color=”grey” align=”align_center”][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/1″][vc_column_text]References<\/em><\/p>\n

1. Jacobs PP, Callewaert N. (2009)\u00a0Curr Mol Med. 9(7):774-800. PMID:\u00a019860659
\n<\/a>2. Hossler P, Khattak SF, Li ZJ. (2009)\u00a0Glycobiology. 19(9):936-49. PMID:\u00a019494347
\n<\/a>3. Cosmi B, Palareti G. (2012)\u00a0Thromb Res.\u00a0129(3):388-91\u00a0PMID:\u00a022137740
\n<\/a>4. Lepenies B, Seeberger PH. (2010)\u00a0Immunopharmacol Immunotoxicol.\u00a032(2):196-207. PMID:\u00a020141495<\/a><\/em>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column width=”1\/1″][vc_column_text]The relevance of glycobiology goes beyond the importance for basic studies of cell biology. Currently, glycoprotein and carbohydrate-based drugs and therapeutics represent a greater than $20 billion market (1-4). A very important set of therapeutic glycoproteins are recombinant monoclonal antibodies (rMAbs). They can effectively inhibit TNF-\u03b1 and thus control the symptoms of rheumatoid arthritis,… Read more »<\/a><\/p>\n","protected":false},"author":15,"featured_media":1680,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"page-sidebar-glycobiology.php","meta":{"footnotes":""},"class_list":["post-2233","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nGlycobiology - New England Biolabs France<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.neb-online.fr\/en\/glycobiology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glycobiology - New England Biolabs France\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=”1\/1″][vc_column_text]The relevance of glycobiology goes beyond the importance for basic studies of cell biology. 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